The DNA Dimmer Dial:

How mRNA Vaccines Create Cellular Memory and Leave a Lasting Mark on Your Immune System

April 11, 2025

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A Message from Dr. McMillan

Over the past 18 months, I’ve focused intensely on understanding the complex spectrum of illness triggered by re-exposure to COVID-19 - what I’ve come to describe as the COVID STORM (Spike Triggered autOimmune Response Mechanism).

This work has led to an important insight: macrophage hyperactivation, potentially triggered in some individuals after mRNA vaccination, may play a key role in long-term vascular complications.

This emerging understanding sheds light on a previously overlooked aspect of the pandemic’s health impact, and may help explain persistent symptoms and risks many are still facing.

As always, thank you for being part of this ongoing journey to uncover the deeper truths behind COVID-19.

Dr. Philip McMillan

In this week's April 11, 2025 update:

  • COVID-19: How mRNA vaccines change your immune system DNA

  • Vejon: This week’s featured Vejon video

  • Health: Common habits that damage your kidneys

  • Infographic: The DNA dimmer dial

  • News: Medical news in brief

  • Education: McMillan root spike detox protocol

    Read time: 6 minutes

FEATURE ARTICLE

COVID-19

  • mRNA vaccines create epigenetic modifications in macrophages that persist for at least six months after vaccination.

  • These changes involve histone acetylation (H3K27ac) that keeps immune response genes in an accessible state.

  • Two consecutive vaccinations are required for this persistent epigenetic memory to develop in macrophages.

  • Some researchers worry these changes may keep immune cells constantly activated, potentially causing chronic inflammation.

Why this is important: By rewriting our DNA expression without altering its sequence, mRNA vaccines don't just trigger antibodies but create lasting epigenetic "dimmer switches" in macrophages. This mechanism explains both the limited effectiveness of mRNA vaccines and the potentially-concerning long-term inflammatory responses to them in certain individuals. It also fundamentally alters our understanding of vaccine immunity..

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HEALTH

  • Over 10% of the UK population has chronic kidney disease, with 600,000 developing acute kidney injury annually.

  • Kidneys filter waste, regulate blood pressure, support red blood cell production, and maintain calcium balance.

  • Kidney damage can lead to toxin buildup, fluid retention, electrolyte imbalance, and eventually chronic kidney disease.

  • Simple lifestyle changes can protect kidney health and prevent damage throughout the body.

Why this is important: Protecting kidney health extends beyond renal function and safeguards your entire body. By avoiding common habits like overusing painkillers, dehydration, and consuming ultra-processed foods, you may prevent cascading health problems including high blood pressure, heart disease, and eventual kidney failure.

INFOGRAPHIC

EDUCATION

McMillan ROOT Spike Detox Protocol

You don’t have to settle for feeling anything less than your best. The McMillan ROOT Spike Detox Protocol is designed to give you a clear roadmap to better health and lasting results. Complete our survey, get the link on submission to book a Check-In with Dr McMillan and start your journey back to health. Note that all meetings are scheduled in UK time.

MEDICAL NEWS IN BRIEF

NEWS HIGHLIGHTS

🚥 Traditional Tanzanian Diet Curbs Inflammation and May Help Prevent Chronic Disease: Tanzanian heritage meals with fiber-rich plants, whole grains and beans reduced inflammation when Westernized eaters switched diets. Effects persisted a month later. This suggests traditional East African nutrition could combat chronic diseases globally while highlighting the urgent need to preserve disappearing food cultures before rapid urbanization eliminates these potential health solutions. [SOURCE]

🚥 A Revolutionary Antiviral Compound Shows Promise in Preventing Long COVID Symptoms: This antiviral treatment breakthrough represents the first potential defense against long COVID, a condition affecting millions with no current remedies. By targeting the PLpro protein instead of Mpro, it not only prevents debilitating brain and lung symptoms but may also overcome limitations of existing COVID treatments. [SOURCE]

🚥 Urine Therapy: Ancient Practice Persists Despite Health Risks: Ancient beliefs about urine therapy persist despite scientific evidence revealing potential health risks - bacterial contamination, accelerated dehydration, and drug toxicity. Understanding this disconnect between cultural practices and medical science helps protect public health while respecting traditional knowledge systems.

🚥 Cell Stiffening: The Hidden Culprit Behind Aging Bones: Discovering how osteocytes stiffen with age reveals why bones weaken over time. By identifying these mechanical changes rather than just genetic markers, scientists can develop targeted treatments that could reverse cellular aging and potentially revolutionize osteoporosis care for millions of aging adults worldwide. [SOURCE]

🚥 Pharmaceutical Naming Systems: Coded Communication for Safety and Clarity: Drug naming patterns serve as a global medical language, balancing scientific precision with clarity. Yet these complex conventions create dangerous medication mix-ups. Understanding why pharmaceutical tongue-twisters exist reveals their purpose beyond marketing - they're coded communications essential for healthcare safety worldwide.

🚥 Brain's Hunger Signal Reshapes Immune Response Without Actual Fasting: Hunger perception alone, not just nutrient deprivation, reshapes immune function. The brain's hypothalamus directly triggers immune cell reorganization during fasting, explaining links between obesity and inflammation. This mind-body connection reveals new therapeutic pathways for inflammatory diseases, cancer-related wasting, and infections - potentially revolutionizing treatment approaches beyond simple caloric interventions. [SOURCE]

BOOK NOOK

"Disease X: Are You Prepared?" is your comprehensive guide to navigating the uncertain future of global health. Drawing from experience and the latest scientific insights, this book offers:

  • Practical strategies for personal and community preparedness.

  • Lessons learned from COVID-19 and other outbreaks.

  • Actionable steps to boost resilience against emerging health threats.

Set within a child’s nose, ‘Humming Heroes’ features a family of Lymphocytes led by a wise Mother, brave Father, determined Brother, and heroic Baby, confronting invading microorganisms. The story takes an imaginative turn, when a humming melody combines with the Lymphocytes’ song to repel the invaders and restore inner harmony.

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