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Commonly used antibiotic linked to serious complications and death in sickest patients

Critically ill patients given piperacillin/tazobactam had higher mortality rates than those given cefepime, possibly due to the antibiotic's impact on gut bacteria.

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Welcome, Health Advocates!

In this week’s May 14, 2024 update:

  • Medications: Common antibiotic linked to serious complications

  • Vejon: Highlights of the week from Vejon Health

  • Alzheimer’s: Glutamate tRNA plays a crucial role in Alzheimer's

  • Health: Sleep may not clear brain toxins

  • Lumigraphic: Visualizing the Body’s Inflammatory Response

  • News: Medical News in Brief

  • Book Nook: Publications that may interest you

  • Chat Vejon: Ask our AI Expert relevant medical questions

    Read time: 5 minutes



  • A national shortage of the antibiotic piperacillin/tazobactam allowed researchers to compare patient outcomes on different antibiotics.

  • In patients with sepsis, those given piperacillin/tazobactam had higher rates of death and complications than those given cefepime.

  • Piperacillin/tazobactam targets anaerobic bacteria in the gut, which may lead to disruption of the microbiome and worse outcomes.

  • Physicians should carefully consider whether anti-anaerobic antibiotics are necessary before prescribing them to critically ill patients.

Why is this Important: Critically ill patients given piperacillin/tazobactam had higher mortality rates than those given cefepime, possibly due to the antibiotic's impact on gut bacteria. This finding highlights the importance of carefully considering the potential risks of certain antibiotics before administering them to the sickest patients.


Vejon Video Highlights of the Week


  • Glutamate tRNA fragments accumulate in the aging brain and are linked to cognitive decline and Alzheimer's disease.

  • These fragments disrupt protein synthesis and activate immune pathways, contributing to neurodegeneration.

  • Reducing glutamate tRNA fragment levels improved cognition and reduced Alzheimer's pathology in mice.

  • Targeting these fragments could be a potential therapeutic approach for age-related cognitive decline and Alzheimer's.

Why is this Important: Identifying the critical role of glutamate tRNA fragments in brain aging and Alzheimer's opens new avenues for developing targeted therapies to delay cognitive decline and treat neurodegenerative diseases by reducing the accumulation of these fragments and restoring mitochondrial function in the aging brain.



  • A new study challenges the leading theory that sleep helps the brain flush out toxins.

  • In mice, toxin clearance and fluid movement in the brain were reduced during sleep and anesthesia.

  • The study suggests being awake, active, and exercising may more efficiently clean the brain of toxins.

  • Researchers aim to uncover how sleep reduces toxin clearance in mice and if findings apply to humans.

Why is this Important: Challenging the prevailing theory, this groundbreaking research suggests that being awake and active may be more effective for clearing brain toxins than sleep, potentially revolutionizing our understanding of the brain's self-cleaning mechanisms and the fundamental reasons why we sleep.


  • ChatGPT accurately analyzed over 700 lung cancer pathology notes to extract key tumor features and staging.

  • ChatGPT extracted cancer grade and margin status from 191 osteosarcoma clinical notes with nearly 99-100% accuracy.

  • Using ChatGPT to extract structured data from clinical notes could accelerate research and aid clinical trial enrollment.

  • Rigorous, continuous evaluation of ChatGPT is crucial when applying it to clinical data, despite its promising potential.

Why is this Important: ChatGPT's ability to accurately extract structured data from clinical notes could accelerate medical research, aid clinical trial enrollment, and enhance clinical decision-making. However, rigorous and continuous evaluation of the AI technology is crucial when applying it to sensitive healthcare data, despite its immense potential to revolutionize the field.



Discover Our AI-Powered Chatbot!

We are excited to introduce our AI-powered Chatbot, trained on transcripts from over 100+ videos in the Vejon Health knowledgebase. Currently, about 30% (100 of 350+) of the content has been transcribed, indexed, and added to the database, providing you with instant access to a wealth of health information.

We are committed to expanding our chatbot's knowledge base, with the remaining videos being added over the next few weeks. Stay tuned for upcoming announcements about the future of health support powered by the Vejon Health knowledgebase!



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🚥 What makes a memory?: Understanding how the brain prioritizes and encodes memories could lead to new strategies for enhancing learning and treating memory disorders. By suggesting that less predictable information is more memorable, this research provides a fresh perspective on the fundamental mechanisms of memory formation and their real-world implications.

🚥 Variations in ancient immune cells linked to modern disease risk: Identifying variations in ancient immune cell profiles linked to modern disease risk opens new avenues for personalized medicine, allowing doctors to tailor treatments based on a patient's specific immune profile and potentially improve outcomes for diseases that have evolved alongside our immune systems over centuries.

🚥 First person to receive genetically modified pig kidney transplant dies: There is objective evidence that COVID-19 infection can lead to measurable cognitive impairment, especially in those with severe illness or long COVID, highlighting the need for further research into prevention, treatment, and support for affected individuals.

🚥 Uniquely human gene enhances immune function in some people: The immune-enhancing role of the uniquely human CHRFAM7A gene provides insights into how our immune system evolved enhanced capabilities compared to other primates.[2][3] This opens up avenues for leveraging this gene to develop new immunotherapies.

🚥 Compounds from Gut Bacteria Show Potential in Reducing Inflammation: A study has identified natural gut bacteria compounds that can regulate a key nuclear receptor involved in inflammation and metabolic diseases, offering promising drug candidates without side effects observed with synthetic compounds.

🚥 New drug candidate reverses obesity and improves metabolic health in mice: Scientists have found a promising new drug candidate that could potentially treat obesity and related metabolic disorders by targeting a specific enzyme involved in purine synthesis. If the findings translate to humans, this could lead to the development of novel therapies for obesity, improving health outcomes for millions of people.



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